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Human sirtuins function as intracellular regulatory proteins. Sirtuin 2 is a member of the class III histone deacetylases (HDACs) an d has been implicated in many cellular processes that include histone deacetylation, gene silencing Item Number: BIOV6632-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Proteins expressed in the endoplasmic reticulum (ER) are tightly regulated by a variety of quality control mechanisms. Terminally mi sfolded proteins in the ER are retrotranslocated to the cytoplasm and degraded by proteasomes Item Number: BIOV6633-100 Unit of Measure: 100 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request	Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat c ells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentia Item Number: BIOV6635-50 Unit of Measure: 50 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	TIP60 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT interactive prote in. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes Item Number: BIOV6634-50 Unit of Measure: 50 MCG Packaging: Vial 259.00 CHF 259.0 CHF Current delivery time on request
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histon Item Number: BIOV6639-100 Unit of Measure: 100 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request	IL-10 (Interleukin-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF), is an 20.5 kDa protein containing 161-178 a mino acid residues. IL10 is produced primarily by monocytes and to a lesser extent by lymphocytes. Item Number: BIOV6638-100 Unit of Measure: 100 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request	Procalcitonin is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under norm al expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal Item Number: BIOV6640-100 Unit of Measure: 100 MCG Packaging: Vial 259.00 CHF 259.0 CHF Current delivery time on request	Superoxide Dismutase (SOD) is an oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecula r oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. Item Number: BIOV6641-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in prot eins that regulate transcription. BrdT drives a meiotic and post-meiotic gene expression program. Item Number: BIOV6643-100 Unit of Measure: 100 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request	CARTEOLOL HYDROCHLORIDE, UoM: 1 * 5 g Item Number: ACRO464320050 Unit of Measure: 5 G Packaging: Glass bottle 408.00 CHF 408.0 CHF Current delivery time on request	Members of the glial cell line-derived neurotropic factor (GDNF) family, including GDNF and neuturin (NTN), play key roles in the co ntrol of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence Item Number: BIOV6401-05 Unit of Measure: 500 ML Packaging: Vial 284.00 CHF 284.0 CHF Current delivery time on request	Rabbit anti-mouse IgG (H+L), horseradish Peroxidase (HPR) conjμgated. This antibody has been optimized as secondary antibody in che miluminescent Western blotting applications Item Number: BIOV6402-05 Unit of Measure: 500 ML Packaging: Vial 284.00 CHF 284.0 CHF Current delivery time on request
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histon Item Number: BIOV6644-100 Unit of Measure: 100 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request	Synapsins are abundant brain proteins essential for regulating neurotransmitter release. All synapsins contain a short N-terminal do main that is highly conserved and phosphorylated by PKA or CaM kinase I. Phosphorylation of synapsin N-termi Item Number: BIOV6008-100 Unit of Measure: 100 MCG Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request	The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to ca talyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose Item Number: BIOV6107-50 Unit of Measure: 50 MCG Packaging: Vial 259.00 CHF 259.0 CHF Current delivery time on request	Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which al so includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or Item Number: BIOV6109-50 Unit of Measure: 50 MCG Packaging: Vial 284.00 CHF 284.0 CHF Current delivery time on request
Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 Item Number: BIOV6645-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the b one matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin Item Number: BIOV6647-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Stem cell factor / KIT ligand (SCF) is a cytokine which binds CD117(c-Kit). SCF is also known as "steel factor" or "c-kit ligand". S CF exists in two forms; cell surface bound SCF and soluble (or free) SCF. Item Number: BIOV6646-100 Unit of Measure: 100 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request	Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 Item Number: BIOV6650-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request

VWR / Merck Chemicals