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PTEN (phosphatase and tensin homologue deleted on chromosome ten) phosphatase is a tumor suppressor gene implicated in a wide variet y of human cancers. PTEN encodes the 403 amino acid polypeptide originally described as a dual-specificity p Item Number: BIOV3479-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essentia l for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembr Item Number: BIOV3555R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	MAP kinase-activated protein kinase-2 (MAPKAPK-2), also known as p45 hsp27 kinase, is a 45-54 kDa serine-threonine protein kinase. M APKAPK-2 is rapidly phosphorylated and activated in response to stress, cytokines, and chemotactic factors. Item Number: BIOV3434-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	"p38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a Item Number: BIOV3438-100 Unit of Measure: 100 MCG Packaging: Vial 436.00 CHF 436.0 CHF Current delivery time on request
Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been l inked to early onset of Alzheimer’s disease, probably functioning throμgh its associated g-secretase activit Item Number: BIOV3482-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	HDAC family members have been divided into two classes. Class I of the HDACs comprises four members, HDAC-1, 2, 3, and 8, each of wh ich contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the Item Number: BIOV3609-100 Unit of Measure: 100 MCG Packaging: Vial 379.00 CHF 379.0 CHF Current delivery time on request	The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essentia l for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembr Item Number: BIOV3557-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	JMJD1C is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulat ion and influences transcriptional activation and suppression. Item Number: BIOV3439-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
Rab5 is a 24 kDa GTP-binding protein that is localized to the cytoplasmic side of the plasma membrane, clathrin-coated vesicles, and early endosomes. Rab5 is believed to regulate vesicle fusion throμgh a cycle of GDP/GTP exchange and GTP hy Item Number: BIOV3483-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	POLY-L-LYSINE HBR (MW 4,000 -15,000), UoM: 1 * 1 g Item Number: ICNA0210269191 Unit of Measure: 1 G Packaging: Amber Glass Bottle 2,180.00 CHF 2180.0 CHF Current delivery time on request	The Toll-like receptor (TLR) family in mammalian comprises a family of transmembrane proteins characterized by multiple copies of le ucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Item Number: BIOV3558R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Tumor Endothelial Markers (TEMs, TEM 1-9) are recently identified genes, whose expression is elevated in tumor-associated endotheliu m. TEMs are barely detectable in normal endothelial cells. TEM8 has been shown to interact with C5 domain of Item Number: BIOV3668-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
HDAC family are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold lar Item Number: BIOV3610-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essentia l for Toll-induced signal transduction. TLR9 has been sμggested as a receptor for unmethylated CpG dinucleot Item Number: BIOV3559R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	uPAR (Urokinase plasminogen activator receptor) is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasmino gen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum β-globulin, plasminog Item Number: BIOV3440-100 Unit of Measure: 100 MCG Packaging: Vial 373.00 CHF 373.0 CHF Current delivery time on request	p70 S6 kinase and p90 Rsk kinase are the two distinct 40S ribosomal protein S6 Ser/Thr kinases present in somatic animal cells. p90 Rsk kinase is maximally activated within minutes of addition of growth factors or phorbol ester to cultured Item Number: BIOV3485-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
Both p44 and p42 MAP kinases (Erk1 and Erk2) function in a protein kinase cascade that plays a critical role in the regulation of ce ll growth and differentiation. Activation of MAP kinases occurs throμgh phosphorylation of threonine and tyr Item Number: BIOV3441-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	Cystatin A (acid cysteine proteinase inhibitor, ACPI) is a natural inhibitor of cysteine proteinases and is located mainly in the ke ratohyaline granules of the stratum granulosum and the cornified envelope of the stratum corneum in the epid Item Number: BIOV3486-100 Unit of Measure: 100 MCG Packaging: Vial 373.00 CHF 373.0 CHF Current delivery time on request	Both p44 and p42 MAP kinases (Erk1 and Erk2) function in a protein kinase cascade that plays a critical role in the regulation of ce ll growth and differentiation. Activation of MAP kinases occurs throμgh phosphorylation of threonine and tyr Item Number: BIOV3442-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibod ies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications Item Number: BIOV3612-100 Unit of Measure: 100 4G Packaging: Vial 448.00 CHF 448.0 CHF Current delivery time on request

VWR / Merck Chemicals