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p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activa ting transcription of genes involved either in progression throμgh the cell cycle Numero articolo: BIOV3036R-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	AMPKα (PRKAA1) belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinas e (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. Numero articolo: BIOV3113-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Aktuelle Lieferfrist auf Anfrage	Caspase family of cysteine proteases plays a key role in apoptosis. Caspase-9 is one of the most important caspases among the caspas e family members. Numero articolo: BIOV3037-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	Akt, also referred to as PKB and RAC, is the cellular homologue of the viral oncogene v-Akt. This protein kinase is activated by ins ulin and various growth factors and functions in a pathway involving PI3 kinase as activation is sensitive t Numero articolo: BIOV3257-100 Unità di misura: 100 MCG Imballaggio: Vial 429,00 CHF 429.0 CHF Aktuelle Lieferfrist auf Anfrage
Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase- 8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that lead Numero articolo: BIOV3258-100 Unità di misura: 100 MCG Imballaggio: Vial 442,00 CHF 442.0 CHF Aktuelle Lieferfrist auf Anfrage	The precursor of cytochrome c, apocytochrome c, is synthesized in the cytoplasm. Upon translocation into mitochondria, cytochrome c acquires a heme moiety required for functionality in the mitochondrial respiration chain. Numero articolo: BIOV3187-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Aktuelle Lieferfrist auf Anfrage	Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate t argeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting XD8+ cytotoxic Numero articolo: BIOV3188R-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase- 8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that lead Numero articolo: BIOV3259-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Aktuelle Lieferfrist auf Anfrage
Protein kinase A (PKA) also known as cAMP-dependent protein kinase, is a 40 kDa protein kinase that phosphorylates serine or threoni ne residues in target proteins in response to elevated levels of cAMP. It has been sμggested that the comple Numero articolo: BIOV3115-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	PARD (partitioning-defective) proteins are important in asymmetric cell division and polarized growth. PARD3 plays a vital role in t he formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases Numero articolo: BIOV3260-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Type I calpain requires micromolar amounts of calcium, while type II calpain requires millimolar amounts of calciu Numero articolo: BIOV3189-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	InSolution GSK-3 Inhibitor XVI CHIR99021 Numero articolo: 361571-5MG Unità di misura: 5 MG Imballaggio: Glass bottle 607,00 CHF 607.0 CHF Aktuelle Lieferfrist auf Anfrage
Death Associated Protein 1 (DAP1) is a 15 kDa protein that functions as a positive mediator of cell death initiated by interferon-ga mma. The DAP1 protein is praline-rich and possesses one SH3 binding motif, as well as several consensus prot Numero articolo: BIOV3261-100 Unità di misura: 100 MCG Imballaggio: Vial 360,00 CHF 360.0 CHF Aktuelle Lieferfrist auf Anfrage	TCTN2 is a member of the Tectonic protein family. Tectonic proteins are transmembrane proteins that regulate the Hedgehog (Hh)-signa ling pathway. Defects in TCTN2 can lead to Meckel syndrome type 8. This disorder is characterized by a comb Numero articolo: BIOV3262-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consistin g of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sens Numero articolo: BIOV3117-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Aktuelle Lieferfrist auf Anfrage	The caspase family of cysteine proteases play a key role in apoptosis. Caspase-3 is the most extensively studied apoptotic protein a mong caspase family members. Numero articolo: BIOV3004-100 Unità di misura: 100 MCG Imballaggio: Vial 391,00 CHF 391.0 CHF Aktuelle Lieferfrist auf Anfrage
Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro Numero articolo: BIOV3191R-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Aktuelle Lieferfrist auf Anfrage	Fodrin is a universally expressed membrane-associated cytoskeletal protein consisting of α- and β-subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. α-Fodrin is one of Numero articolo: BIOV3266-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	Cathepsin L is a normal lysosomal cysteine endoproteases that is expressed in all cells. The latent 39 kDa pro-Cathepsin L must be p rocessed by cleavage of the 96 amino acid pro-peptide, to generate the active two-chain form made up of 21 Numero articolo: BIOV3192-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Aktuelle Lieferfrist auf Anfrage	Wee1 is a nuclear tyrosine protein kinase. The protein plays a role in suppressing eukaryotes’ entry into mitosis by inactivating cd c2 kinase by inhibiting tyrosine phosphorylation. The predicted molecular weight of the kinase is 72 kDa. Numero articolo: BIOV3120-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Aktuelle Lieferfrist auf Anfrage

VWR / Merck Prodotti chimici