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Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/c aspase-9 pathway. Smac/DIABLO binds to IAPs (Inhibitor of Apoptosis Proteins) and neutralizes the inhibitor Item Number: BIOV3298-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Cytochrome P450 is mainly found in liver, and can metabolize a wide range of compounds such as organic solvents, acetaminophen, dime thylnitrosoamine and aliphatic alcohol, which have certain toxicological effects in humans. Item Number: BIOV3084R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeleytal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block thr Item Number: BIOV3385-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Elk-1 is a transcription factor that binds the serum response element (SRE) and mediates gene activity in response to serum and grow th factors. Elk-1 is phosphorylated by MAP kinase pathways and appears to be a direct target of activated MA Item Number: BIOV3387-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
Short/branched chain acyl-CoA dehydrogenase(ACADSB) belongs to the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydr ogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Item Number: BIOV3150-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Heat shock proteins (HSPs) are ubiquitously expressed in all organisms. A major function of HSP90 and other HSPs is to act as molecu lar chaperones. HSP90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound rece Item Number: BIOV3389-100 Unit of Measure: 100 MCG Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request	Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases ( PRMTs). PRMT6 catalyzes the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side Item Number: BIOV3086-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative spl icing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic isl Item Number: BIOV3154-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request
Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase-6 is also sy nthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Item Number: BIOV3156-100 Unit of Measure: 100 MCG Packaging: Vial 429.00 CHF 429.0 CHF Current delivery time on request	Short/branched chain acyl-CoA dehydrogenase(ACADSB) belongs to the acyl-CoA dehydrogenase family of enzymes catalyze the dehydrogena tion of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Item Number: BIOV3157-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	The MBD family of proteins includes MeCP2, MBD1, MBD2, MBD3 and MBD4. MBD2 is highly similar to MBD3 but only MBD2 targets the MeCP1 complex to methylate DNA. MBD2 has two isoforms, MBD2a and MBD2b. MBD2a is a 414 amino acids protein Item Number: BIOV3232-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Heme oxygenase-1 (HO-1) or HSP32 is the inducible isoform of heme oxygenase which catalyzes the NADPH, O2 and cytochrome P450 reduct ase dependent oxidation of heme to carbon monoxide, iron and biliverdin that is immediately reduced to bilir Item Number: BIOV3391-100 Unit of Measure: 100 MCG Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request
TCTN1 belongs to the Tectonic protein family that regulate Hedgehog (Hh) pathway. During neural tube development, TCTN1 is required for the formation of most ventral cell types and for full Hh pathway activation. Item Number: BIOV3088-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis throμgh two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-for Item Number: BIOV3312-100 Unit of Measure: 100 MCG Packaging: Vial 360.00 CHF 360.0 CHF Current delivery time on request	Heme oxygenase (HO) is a microsomal enzyme that oxidatively cleaves heme, a pro-oxidant, into carbon monoxide and biliverdin. Two he me oxygenase isozymes, termed HO-1 and HO-2, have been identified so far. Item Number: BIOV3392-100 Unit of Measure: 100 MCG Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request	KLF4 belongs to the erythroid Kruppel-like factor (EKLF) family that is involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Item Number: BIOV3089-200 Unit of Measure: 200 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Cell death signal are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10 Item Number: BIOV3313-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Heterodimers between TCF3 and tissue specific basic helix loop helix (bHLH) proteins play important roles in determining tissue spec ific cell fate during embryogenesis, like muscle or early B cell differentiation. Item Number: BIOV3090-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzyma tic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically Item Number: BIOV3171-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	Erk-5 shares high homology in the amino-terminal kinase domain with Erk1/2. However, the long carboxy-terminal kinase domain makes E rk5 a unique MAP kinase. Erk5 is activated by a variety of extracellular signals. The direct upstream kinase Item Number: BIOV3397-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request

VWR / Merck Chemicals