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VWR / Merck Chemicals

Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. It has also been used as a potential regulator of tumor growth and metastasis. TSP expression is highly regulated by dif
Item Number: BIOV3283-100
Unit of Measure: 100 MCG
Packaging: Vial
347.00 CHF 347.0 CHF
Current delivery time on request
Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-3 is synthesized as an inactive pro-enz yme (32 kDa) that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another
Item Number: BIOV3138-100
Unit of Measure: 100 MCG
Packaging: Vial
360.00 CHF 360.0 CHF
Current delivery time on request
MKK3 is a protein kinase that phosphorylates the p38 MAPK. Phosphorylation by MKK3 occurs on threonine and tyrosine residues and inc reases the activity of p38 to stimulate transcription factors ATF2 and Elk-1. MKK3, together with MKK6, serv
Item Number: BIOV3285-100
Unit of Measure: 100 MCG
Packaging: Vial
335.00 CHF 335.0 CHF
Current delivery time on request
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cat hepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E.
Item Number: BIOV3370-200
Unit of Measure: 200 4G
Packaging: Vial
360.00 CHF 360.0 CHF
Current delivery time on request
Granzyme B is a 27 kDa serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, gra nzyme B is directionally exocytosed and assisted by perforin, enters the target cell.
Item Number: BIOV3073-100
Unit of Measure: 100 MCG
Packaging: Vial
373.00 CHF 373.0 CHF
Current delivery time on request
VENTX is a member of the Vent family of homeodomain proteins. VENTX may function as a transcriptional repressor and involved in meso dermal patterning and hemapoietic stem cell maintenance.
Item Number: BIOV3286-100
Unit of Measure: 100 MCG
Packaging: Vial
309.00 CHF 309.0 CHF
Current delivery time on request
ASC (also called TMS1) is a CARD domain containing protein. ASC induces apoptosis throμgh activation of caspase-9 and inhibiting the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation.
Item Number: BIOV3291-100
Unit of Measure: 100 MCG
Packaging: Vial
309.00 CHF 309.0 CHF
Current delivery time on request
Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and pro grammed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor
Item Number: BIOV3222-100
Unit of Measure: 100 MCG
Packaging: Vial
354.00 CHF 354.0 CHF
Current delivery time on request
TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) fam ily of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form
Item Number: BIOV3222R-100
Unit of Measure: 100 MCG
Packaging: Vial
335.00 CHF 335.0 CHF
Current delivery time on request
Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Calpai n-1 and 2 consist of a common small subunit and a large variable subunit.
Item Number: BIOV3372-100
Unit of Measure: 100 4G
Packaging: Vial
354.00 CHF 354.0 CHF
Current delivery time on request
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavag
Item Number: BIOV3140-100
Unit of Measure: 100 MCG
Packaging: Vial
486.00 CHF 486.0 CHF
Current delivery time on request
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavag
Item Number: BIOV3141-100
Unit of Measure: 100 MCG
Packaging: Vial
461.00 CHF 461.0 CHF
Current delivery time on request
TFPI is also known as lipoprotein­associated coagulation inhibitor (LACI). TFPI encodes a protease inhibitor that regulates the tiss ue factor (TF)-dependent pathway of blood coagulation.
Item Number: BIOV3379-100
Unit of Measure: 100 MCG
Packaging: Vial
341.00 CHF 341.0 CHF
Current delivery time on request
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encod es hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-
Item Number: BIOV3143-100
Unit of Measure: 100 MCG
Packaging: Vial
410.00 CHF 410.0 CHF
Current delivery time on request
Receptor interacting protein including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the de ath receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3.
Item Number: BIOV3293-100
Unit of Measure: 100 MCG
Packaging: Vial
354.00 CHF 354.0 CHF
Current delivery time on request
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are highly conserved proteins and have importa nt roles in the regulation of metabolism, inflammation, cellular survival growth and differentiation.
Item Number: BIOV3224-100
Unit of Measure: 100 MCG
Packaging: Vial
322.00 CHF 322.0 CHF
Current delivery time on request
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an a llosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step
Item Number: BIOV3144-100
Unit of Measure: 100 MCG
Packaging: Vial
410.00 CHF 410.0 CHF
Current delivery time on request
Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus.
Item Number: BIOV3076-100
Unit of Measure: 100 MCG
Packaging: Vial
391.00 CHF 391.0 CHF
Current delivery time on request
PID/MTA2, also termed MTA1-L1, is a novel molecule that has been found to be involved in p53 pathway. PID/MTA2 modulates the enzymat ic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deac
Item Number: BIOV3294-100
Unit of Measure: 100 MCG
Packaging: Vial
335.00 CHF 335.0 CHF
Current delivery time on request
The Storkhead box protein 2 (STOX2) is a winged-helix domain containing transcription factor. STOX2 has been sμggested to be part of a molecular profile unique to stem cells and may play a role in the differentiation of stem cells.
Item Number: BIOV3382-100
Unit of Measure: 100 MCG
Packaging: Vial
309.00 CHF 309.0 CHF
Current delivery time on request