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Caspase family of cysteine proteases plays a key role in apoptosis. Caspase-9 is one of the most important caspases among the caspas e family members. Numero articolo: BIOV3037-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	Akt, also referred to as PKB and RAC, is the cellular homologue of the viral oncogene v-Akt. This protein kinase is activated by ins ulin and various growth factors and functions in a pathway involving PI3 kinase as activation is sensitive t Numero articolo: BIOV3257-100 Unità di misura: 100 MCG Imballaggio: Vial 429,00 CHF 429.0 CHF Tempo di consegna attuale su richiesta	IKKα (IkB kinase-α or IKK-1) is part of a large protein complex responsible for the inducible phosphorylation of IkB proteins. Human IKK-α is an 85 kDa peptide that has been shown to activate NFkB by phosphorylation of IkB proteins. Numero articolo: BIOV3185-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	p38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a cascade controlling cell cellular responses to cytokines and stress. Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular Numero articolo: BIOV3114-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Tempo di consegna attuale su richiesta
Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase- 8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that lead Numero articolo: BIOV3258-100 Unità di misura: 100 MCG Imballaggio: Vial 442,00 CHF 442.0 CHF Tempo di consegna attuale su richiesta	The precursor of cytochrome c, apocytochrome c, is synthesized in the cytoplasm. Upon translocation into mitochondria, cytochrome c acquires a heme moiety required for functionality in the mitochondrial respiration chain. Numero articolo: BIOV3187-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta	Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate t argeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting XD8+ cytotoxic Numero articolo: BIOV3188R-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase- 8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that lead Numero articolo: BIOV3259-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta
Protein kinase A (PKA) also known as cAMP-dependent protein kinase, is a 40 kDa protein kinase that phosphorylates serine or threoni ne residues in target proteins in response to elevated levels of cAMP. It has been sμggested that the comple Numero articolo: BIOV3115-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	PARD (partitioning-defective) proteins are important in asymmetric cell division and polarized growth. PARD3 plays a vital role in t he formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases Numero articolo: BIOV3260-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Type I calpain requires micromolar amounts of calcium, while type II calpain requires millimolar amounts of calciu Numero articolo: BIOV3189-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	InSolution GSK-3 Inhibitor XVI CHIR99021 Numero articolo: 361571-5MG Unità di misura: 5 MG Imballaggio: Glass bottle 607,00 CHF 607.0 CHF Tempo di consegna attuale su richiesta
Death Associated Protein 1 (DAP1) is a 15 kDa protein that functions as a positive mediator of cell death initiated by interferon-ga mma. The DAP1 protein is praline-rich and possesses one SH3 binding motif, as well as several consensus prot Numero articolo: BIOV3261-100 Unità di misura: 100 MCG Imballaggio: Vial 360,00 CHF 360.0 CHF Tempo di consegna attuale su richiesta	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. Numero articolo: BIOV3000-100 Unità di misura: 100 MCG Imballaggio: Vial 373,00 CHF 373.0 CHF Tempo di consegna attuale su richiesta	Human Raf1 is a proto-oncogene-encoded 74 kDa kinase that serves as an upstream activator of Mek1 by phosphorylating Ser-218 and Ser -222 in the MAP kinase kinase (Mek1). It has also been implicated in the phosphorylation and activation Numero articolo: BIOV3116-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	TCTN2 is a member of the Tectonic protein family. Tectonic proteins are transmembrane proteins that regulate the Hedgehog (Hh)-signa ling pathway. Defects in TCTN2 can lead to Meckel syndrome type 8. This disorder is characterized by a comb Numero articolo: BIOV3262-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consistin g of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sens Numero articolo: BIOV3117-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. Numero articolo: BIOV3002-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	The caspase family of cysteine proteases play a key role in apoptosis. Caspase-3 is the most extensively studied apoptotic protein a mong caspase family members. Numero articolo: BIOV3004-100 Unità di misura: 100 MCG Imballaggio: Vial 391,00 CHF 391.0 CHF Tempo di consegna attuale su richiesta	TRAIL (TNF-related apoptosis-inducing ligand), a member of the TNF ligand family, is a type II membrane protein and expressed in a v ariety of human tissues. Numero articolo: BIOV3045-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta

VWR / Merck Prodotti chimici